Kinetic release studies of nitrogen-containing bisphosphonate from gum acacia crosslinked hydrogels

B A Aderibigbe; K Varaprasad; E R Sadiku; S S Ray; X Y Mbianda; M C Fotsing; S J Owonubi; S C Agwuncha

doi:10.1016/j.ijbiomac.2014.10.064

Kinetic release studies of nitrogen-containing bisphosphonate from gum acacia crosslinked hydrogels

Int J Biol Macromol. 2015 Feb:73:115-23. doi: 10.1016/j.ijbiomac.2014.10.064. Epub 2014 Nov 21.

Authors

B A Aderibigbe¹, K Varaprasad², E R Sadiku³, S S Ray⁴, X Y Mbianda⁵, M C Fotsing⁵, S J Owonubi³, S C Agwuncha³

Affiliations

¹ Department of Chemistry, University of Fort Hare, Alice Campus, Eastern Cape, South Africa. Electronic address: blessingaderibigbe@gmail.com.
² Department of Chemical, Metallurgical and Material Engineering, Tshwane University of Technology, Pretoria 0001, South Africa; Centre de Investigación de Polimeros Avanzados, CIPA, Beltràn Mathieu 224, piso 2, Concepción, Chile.
³ Department of Chemical, Metallurgical and Material Engineering, Tshwane University of Technology, Pretoria 0001, South Africa.
⁴ DST/CSIR National Centre for Nanostructured Materials, Council for Scientific and Industrial Research, Pretoria 0001, South Africa; Department of Applied Chemistry, University of Johannesburg, Doornfontein 2028, Johannesburg, South Africa.
⁵ Department of Applied Chemistry, University of Johannesburg, Doornfontein 2028, Johannesburg, South Africa.

PMID: 25445681
DOI: 10.1016/j.ijbiomac.2014.10.064

Abstract

Natural polymer hydrogels are useful for controlling release of drugs. In this study, hydrogels containing gum acacia were synthesized by free-radical polymerization of acrylamide with gum acacia. The effect of gum acacia in the hydrogels on the release mechanism of nitrogen-containing bisphosphonate (BP) was studied at pH 1.2 and 7.4. The hydrogels exhibited high swelling ratios at pH 7.4 and low swelling ratios at pH 1.2. The release study was performed using UV-Visible spectroscopy via complex formation with Fe(III) ions. At pH 1.2, the release profile was found to be anomalous while at pH 7.4, the release kinetic of BP was a perfect zero-order release mechanism. The hydrogels were found to be pH-sensitive and the release profiles of the BP were found to be influenced by the degree of crosslinking of the hydrogel network with gum acacia. The preliminary results suggest that these hydrogels are promising devices for controlled delivery of bisphosphonate to the gastrointestinal region.

Keywords: Bisphosphonate; Gum acacia.; Hydrogel.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Diphosphonates / administration & dosage
Diphosphonates / chemistry*
Drug Carriers / chemistry
Drug Delivery Systems
Drug Liberation
Gum Arabic / chemistry*
Hydrogels / chemistry*
Kinetics
Molecular Structure
Nitrogen / chemistry*
Polymers / chemistry
Spectrum Analysis

Substances

Diphosphonates
Drug Carriers
Hydrogels
Polymers
Gum Arabic
Nitrogen