Time to overcome the high, long, and bumpy free energy barrier in a multi-stage process: the generalized steady-state approach

Alexei V Finkelstein

doi:10.1021/jp5109703

Time to overcome the high, long, and bumpy free energy barrier in a multi-stage process: the generalized steady-state approach

J Phys Chem B. 2015 Jan 8;119(1):158-63. doi: 10.1021/jp5109703. Epub 2014 Dec 19.

Author

Alexei V Finkelstein¹

Affiliation

¹ Laboratory of Protein Physics, Institute of Protein Research, Russian Academy of Sciences , 142290, Pushchino, Moscow Region, Russian Federation.

PMID: 25478873
DOI: 10.1021/jp5109703

Abstract

This paper presents a simple but general analytical estimate of the characteristic time of crossing a long, high, and arbitrary bumpy free energy barrier in the course of a sequential (one-dimensional) chemical, biochemical, or physical reaction. This estimate is based on a generalized steady-state approach developed in this paper.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Thermodynamics*
Time Factors