Opioid receptor affinities of the blood-derived tetrapeptides hemorphin and cytochrophin

Eur J Pharmacol. 1989 Aug 3;166(3):523-6. doi: 10.1016/0014-2999(89)90368-3.

Abstract

Hemorphin-4 and cytochrophin-4 displayed affinities for mu- and delta-opioid receptors that were in the same range as those observed for the structurally related beta-casomorphins. However, they showed markedly higher affinities at kappa-opioid binding sites when compared to the beta-casomorphins. These blood-derived peptides could be involved in blood pressure regulation.

MeSH terms

  • Animals
  • Brain Chemistry
  • Cyclazocine / analogs & derivatives
  • Cyclazocine / pharmacology
  • Endorphins / pharmacology*
  • Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
  • Enkephalin, Leucine / analogs & derivatives
  • Enkephalin, Leucine / pharmacology
  • Enkephalin, Leucine-2-Alanine
  • Enkephalins / pharmacology
  • Ethylketocyclazocine
  • Female
  • Guinea Pigs
  • Hemoglobins / pharmacology*
  • In Vitro Techniques
  • Male
  • Peptide Fragments / pharmacology*
  • Rats
  • Rats, Inbred Strains
  • Receptors, Opioid / drug effects*
  • Receptors, Opioid / metabolism
  • Receptors, Opioid, delta
  • Receptors, Opioid, kappa
  • Receptors, Opioid, mu

Substances

  • Endorphins
  • Enkephalins
  • Hemoglobins
  • Peptide Fragments
  • Receptors, Opioid
  • Receptors, Opioid, delta
  • Receptors, Opioid, kappa
  • Receptors, Opioid, mu
  • Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
  • hemorphin 4
  • Ethylketocyclazocine
  • Enkephalin, Leucine
  • Enkephalin, Leucine-2-Alanine
  • beta-casomorphins
  • cytochrophin-4
  • Cyclazocine