Abstract
Hemorphin-4 and cytochrophin-4 displayed affinities for mu- and delta-opioid receptors that were in the same range as those observed for the structurally related beta-casomorphins. However, they showed markedly higher affinities at kappa-opioid binding sites when compared to the beta-casomorphins. These blood-derived peptides could be involved in blood pressure regulation.
MeSH terms
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Animals
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Brain Chemistry
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Cyclazocine / analogs & derivatives
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Cyclazocine / pharmacology
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Endorphins / pharmacology*
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Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
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Enkephalin, Leucine / analogs & derivatives
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Enkephalin, Leucine / pharmacology
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Enkephalin, Leucine-2-Alanine
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Enkephalins / pharmacology
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Ethylketocyclazocine
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Female
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Guinea Pigs
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Hemoglobins / pharmacology*
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In Vitro Techniques
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Male
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Peptide Fragments / pharmacology*
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Rats
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Rats, Inbred Strains
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Receptors, Opioid / drug effects*
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Receptors, Opioid / metabolism
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Receptors, Opioid, delta
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Receptors, Opioid, kappa
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Receptors, Opioid, mu
Substances
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Endorphins
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Enkephalins
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Hemoglobins
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Peptide Fragments
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Receptors, Opioid
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Receptors, Opioid, delta
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Receptors, Opioid, kappa
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Receptors, Opioid, mu
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Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
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hemorphin 4
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Ethylketocyclazocine
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Enkephalin, Leucine
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Enkephalin, Leucine-2-Alanine
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beta-casomorphins
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cytochrophin-4
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Cyclazocine