Lack of effect of repirinast on the pharmacokinetics of theophylline in asthmatic patients

K Takagi; T Kuzuya; T Horiuchi; M Nadai; R Apichartpichean; Y Ogura; T Hasegawa

doi:10.1007/BF00679789

Lack of effect of repirinast on the pharmacokinetics of theophylline in asthmatic patients

Eur J Clin Pharmacol. 1989;37(3):301-3. doi: 10.1007/BF00679789.

Authors

K Takagi¹, T Kuzuya, T Horiuchi, M Nadai, R Apichartpichean, Y Ogura, T Hasegawa

Affiliation

¹ Second Department of Internal Medicine, Nagoya University School of Medicine, Japan.

PMID: 2558890
DOI: 10.1007/BF00679789

Abstract

A possible pharmacokinetic interaction between theophylline and repirinast has been investigated in asthmatic patients. The kinetics of theophylline was studied in seven adult in-patients given theophylline 400-800 mg b.d. alone and after three weeks of co-administration of repirinast. There was no effect on the kinetics of the combined treatment.

MeSH terms

Aged
Asthma / drug therapy
Asthma / metabolism*
Delayed-Action Preparations
Drug Interactions
Female
Histamine Antagonists / pharmacology*
Humans
Male
Middle Aged
Quinolones / adverse effects
Quinolones / pharmacology*
Theophylline / administration & dosage
Theophylline / pharmacokinetics*

Substances

Delayed-Action Preparations
Histamine Antagonists
Quinolones
repirinast
Theophylline