Is hormonal treatment still an option in acne today?

Br J Dermatol. 2015 Jul:172 Suppl 1:37-46. doi: 10.1111/bjd.13681.

Abstract

Hormonal treatment is indicated in cases of papulopustular, nodular and conglobate acne in females with identified hyperandrogenism, in adult women who have monthly flare-ups and when standard therapeutic options are unsuccessful or inappropriate. This review summarizes the latest information on hormonal therapies including: combined oral contraceptives; anti-androgens, such as cyproterone acetate, spironolactone and flutamide; low-dose glucocorticoids and gonadotropin-releasing hormone agonists. It also shares the authors' recommendations for treatment based on the studies discussed here, and personal experience.

Publication types

  • Review

MeSH terms

  • Acne Vulgaris / drug therapy*
  • Acne Vulgaris / etiology
  • Adrenal Cortex Hormones / therapeutic use
  • Adult
  • Androgen Antagonists / therapeutic use
  • Contraceptives, Oral, Hormonal / therapeutic use*
  • Cyproterone Acetate / therapeutic use
  • Female
  • Flutamide / therapeutic use
  • Gonadotropin-Releasing Hormone / agonists
  • Hormones / therapeutic use*
  • Humans
  • Hyperandrogenism / complications
  • Spironolactone / therapeutic use

Substances

  • Adrenal Cortex Hormones
  • Androgen Antagonists
  • Contraceptives, Oral, Hormonal
  • Hormones
  • Spironolactone
  • Gonadotropin-Releasing Hormone
  • Cyproterone Acetate
  • Flutamide

Supplementary concepts

  • Acne, Adult