Mitochondrial donation--how many women could benefit?

N Engl J Med. 2015 Feb 26;372(9):885-887. doi: 10.1056/NEJMc1500960. Epub 2015 Jan 28.

Abstract

Mitochondrial disease is maternally inherited and refractory to treatment, but assisted reproduction methods can result in unaffected pregnancies. The authors provide estimates of the number of affected pregnancies per year in the United Kingdom and the United States.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Birth Rate
  • DNA, Mitochondrial*
  • Female
  • Fertility*
  • Fertilization in Vitro / legislation & jurisprudence*
  • Government Regulation*
  • Humans
  • Mitochondria / transplantation*
  • Mitochondrial Diseases / genetics*
  • Mutation*
  • United Kingdom / epidemiology
  • Young Adult

Substances

  • DNA, Mitochondrial