Nephrotic syndrome: from toddlers to twenties

Lancet. 1989 Feb 4;1(8632):255-9. doi: 10.1016/s0140-6736(89)91266-x.

Abstract

63 patients with steroid-sensitive, biopsy-proven minimal-change nephrotic syndrome were followed for between 10 and 21 years. 2 died. All the survivors had normal renal function and blood pressure, and only 2 had a single attack. Frequent relapse was more common with young age of onset and in boys. The frequency of relapse fell rapidly over the first 4 years after diagnosis and then plateaued. Relapses continued into adult life. No definite endpoint to the disease could be defined although there was a linear relation between length of remission and risk of subsequent relapse.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Child
  • Child, Preschool
  • Cyclophosphamide / administration & dosage
  • Cyclophosphamide / therapeutic use
  • Drug Administration Schedule
  • Female
  • Follow-Up Studies
  • Humans
  • Infant
  • Male
  • Nephrotic Syndrome / drug therapy
  • Nephrotic Syndrome / physiopathology*
  • Prednisolone / administration & dosage
  • Prednisolone / therapeutic use
  • Prognosis
  • Recurrence
  • Remission Induction
  • Sex Factors

Substances

  • Cyclophosphamide
  • Prednisolone