Abstract
In the in vitro rat dentate gyrus, norepinephrine-induced long-lasting potentiation (NELLP) and long-term potentiation (LTP) of responses to perforant path stimulation were blocked by the N-methyl-D-aspartate (NMDA) receptor antagonists, D(-)-2-amino-5-phosphonovaleric acid (D(-)APV) and 3-[(+/-)-2-carboxypiperazin-4-yl]propyl-1-phosphonic acid (CPP). CPP and D(-)APV, but not L(+)APV, also depressed the orthodromic population spike but not the antidromic spike, which suggests that these receptors may function in low-frequency evoked activity of granule cells. We conclude that NELLP, like LTP in the dentate gyrus, requires NMDA receptor activation.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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2-Amino-5-phosphonovalerate
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Action Potentials / drug effects
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Animals
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Hippocampus / drug effects
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Hippocampus / metabolism
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Hippocampus / physiology*
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In Vitro Techniques
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Male
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Norepinephrine / pharmacology*
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Piperazines / pharmacology*
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Rats
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Rats, Inbred Strains
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Reaction Time
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Receptors, N-Methyl-D-Aspartate
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Receptors, Neurotransmitter / drug effects
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Receptors, Neurotransmitter / physiology*
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Valine / analogs & derivatives*
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Valine / pharmacology
Substances
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Piperazines
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Receptors, N-Methyl-D-Aspartate
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Receptors, Neurotransmitter
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2-Amino-5-phosphonovalerate
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3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid
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Valine
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Norepinephrine