Oocyte donation in 61 patients

Lancet. 1989 May 27;1(8648):1185-7. doi: 10.1016/s0140-6736(89)92762-1.

Abstract

Oocyte donation was performed by gamete intrafallopian transfer in 61 women, 34 of whom were amenorrhoeic. The mean age of the donors was 32 years (range 23-38). Seventy-five treatment cycles gave 29 clinical pregnancies, of which 21 reached term, 3 continue, and 5 were lost (3 miscarriages, 1 tubal, and 1 cervical). 11 (38%) of the women who became pregnant were over 42 years old. When more than four oocytes were transferred, many of the pregnancies were multiple. 8 (38%) of the pregnancies that came to term were complicated by pre-eclamptic toxaemia. When oocytes are obtained from young women, the fertility potential is high irrespective of the recipient's age.

Publication types

  • Comparative Study

MeSH terms

  • Administration, Sublingual
  • Adult
  • Aging / drug effects
  • Embryo Implantation*
  • Estrogens / administration & dosage
  • Estrogens / pharmacology
  • Female
  • Gamete Intrafallopian Transfer*
  • Humans
  • Infant, Newborn
  • Maternal Age
  • Menstrual Cycle / drug effects
  • Middle Aged
  • Oocytes*
  • Ovulation Induction / methods
  • Pre-Eclampsia / complications
  • Pregnancy
  • Pregnancy, High-Risk
  • Pregnancy, Multiple
  • Progesterone

Substances

  • Estrogens
  • Progesterone