Sustained effects of a protein 'preload' on glycaemia and gastric emptying over 4 weeks in patients with type 2 diabetes: A randomized clinical trial

Diabetes Res Clin Pract. 2015 May;108(2):e31-4. doi: 10.1016/j.diabres.2015.02.019. Epub 2015 Feb 25.

Abstract

We have shown that the capacity of 25g whey preloads to slow gastric emptying and reduce postprandial glycaemia persists after 4 weeks regular exposure in patients with diet-controlled type 2 diabetes. This dietary strategy therefore appears feasible for larger clinical trials to evaluate beneficial effects on long-term glycaemic control. Registered with the Australian New Zealand Clinical Trials Registry: ACTRN12614000831684.

Keywords: Fructosamine; Glycated haemoglobin; Scintigraphy; Whey.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Australia
  • Blood Glucose / metabolism
  • Body Mass Index
  • Cross-Over Studies
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / diet therapy*
  • Diabetes Mellitus, Type 2 / physiopathology
  • Dietary Proteins / pharmacology*
  • Dietary Proteins / therapeutic use*
  • Female
  • Gastric Emptying / drug effects*
  • Gastric Emptying / physiology
  • Humans
  • Hyperglycemia / blood
  • Hyperglycemia / diet therapy*
  • Hyperglycemia / physiopathology
  • Male
  • Middle Aged
  • Postprandial Period / physiology
  • Single-Blind Method
  • Time Factors
  • Treatment Outcome
  • Whey Proteins / pharmacology*
  • Whey Proteins / therapeutic use*

Substances

  • Blood Glucose
  • Dietary Proteins
  • Whey Proteins