Neurodegeneration: paying it off with sleep

Alex C Keene; William J Joiner

doi:10.1016/j.cub.2015.02.003

Neurodegeneration: paying it off with sleep

Curr Biol. 2015 Mar 16;25(6):R234-R236. doi: 10.1016/j.cub.2015.02.003.

Authors

Alex C Keene¹, William J Joiner²

Affiliations

¹ Department of Biology, University of Nevada, Reno. Reno, NV 89557, USA. Electronic address: alexckeene@gmail.com.
² Department of Pharmacology, Biomedical Sciences Graduate Program, Neurosciences Graduate Program, and Center for Chronobiology, University of California, San Diego, La Jolla, CA 92093-0636, USA.

Abstract

A new study in fruit flies suggests modulation of neural activity links sleep and Alzheimer's disease. Both sleep loss and amyloid beta increase neural excitability, which reinforces the accumulation of amyloid beta and shortens lifespan.

MeSH terms

Alzheimer Disease / genetics
Alzheimer Disease / pathology
Alzheimer Disease / physiopathology
Amyloid beta-Peptides / genetics
Amyloid beta-Peptides / physiology
Animals
Animals, Genetically Modified
Disease Models, Animal
Drosophila melanogaster / genetics
Drosophila melanogaster / physiology
Humans
Nerve Degeneration / pathology
Nerve Degeneration / physiopathology*
Sleep / physiology*
Sleep Deprivation / pathology
Sleep Deprivation / physiopathology

Substances

Amyloid beta-Peptides

Abstract

MeSH terms

Substances

Grants and funding