Management of acne vulgaris with hormonal therapies in adult female patients

Dermatol Ther. 2015 May-Jun;28(3):166-72. doi: 10.1111/dth.12231. Epub 2015 Apr 6.

Abstract

Acne vulgaris is a very common condition affecting up of 93% of adolescents. Although rare, this disease may persist in adulthood. In adult women with acne (those older than 25 years old), this condition is particularly relevant because of the refractory to conventional therapies, which makes acne a challenge for dermatologists in this group of patients. In order to its potential risk for chronicity and the involvement of visible anatomical sites such as face and upper torso, acne has been associated with a wide spectrum of psychological and social dysfunction such as depression, anxiety, suicidal ideation, somatization, and social inhibition. In particular, adult women with acne have been shown to be adversely impacted by the effect of acne on their quality of life. For the last four decades, dermatologists have used hormonal therapies for the management of acne vulgaris in adult women, which are considered a rational choice given the severity and chronicity of this condition in this group of patients. The aim of this work is to review the hormonal drugs for management of acne.

Keywords: acne; adult women; hormonal therapy.

Publication types

  • Review

MeSH terms

  • Acne Vulgaris / diagnosis
  • Acne Vulgaris / drug therapy*
  • Acne Vulgaris / psychology
  • Adult
  • Contraceptives, Oral, Hormonal / therapeutic use
  • Cost of Illness
  • Cyproterone Acetate / therapeutic use
  • Dermatologic Agents / adverse effects
  • Dermatologic Agents / therapeutic use*
  • Female
  • Flutamide / therapeutic use
  • Hormones / adverse effects
  • Hormones / therapeutic use*
  • Humans
  • Quality of Life
  • Remission Induction
  • Spironolactone / therapeutic use
  • Treatment Outcome

Substances

  • Contraceptives, Oral, Hormonal
  • Dermatologic Agents
  • Hormones
  • Spironolactone
  • Cyproterone Acetate
  • Flutamide