Abstract
Protein ADP-ribosylation is an important posttranslational modification that plays versatile roles in multiple biological processes. ADP-ribosylation is catalyzed by a group of enzymes known as ADP-ribosyltransferases (ARTs). Using nicotinamide adenine dinucleotide (NAD(+)) as the donor, ARTs covalently link single or multiple ADP-ribose moieties from NAD(+) to the substrates, forming mono ADP-ribosylation or poly ADP-ribosylation (PARylation). Novel functions of ARTs and ADPribosylation have been revealed over the past few years. Here we summarize the current knowledge on ARTs and PARylation.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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ADP Ribose Transferases / chemistry
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ADP Ribose Transferases / genetics
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ADP Ribose Transferases / metabolism*
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Animals
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Catalysis
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Chromatin Assembly and Disassembly
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DNA Damage
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Humans
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NAD / metabolism
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Poly(ADP-ribose) Polymerases / chemistry
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Poly(ADP-ribose) Polymerases / genetics
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Poly(ADP-ribose) Polymerases / metabolism
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Protein Binding
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Protein Interaction Domains and Motifs
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Protein Processing, Post-Translational*
Substances
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NAD
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ADP Ribose Transferases
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Poly(ADP-ribose) Polymerases