Bringing Blood Stem Cell Phenotype, Genotype, and Function Closer Together

Wenlian Qiao; Peter W Zandstra

doi:10.1016/j.stem.2015.05.001

Bringing Blood Stem Cell Phenotype, Genotype, and Function Closer Together

Cell Stem Cell. 2015 Jun 4;16(6):574-5. doi: 10.1016/j.stem.2015.05.001.

Authors

Wenlian Qiao¹, Peter W Zandstra²

Affiliations

¹ The Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON M5S 3E1, Canada; The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E1, Canada.
² The Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON M5S 3E1, Canada; The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E1, Canada. Electronic address: peter.zandstra@utoronto.ca.

PMID: 26046754
DOI: 10.1016/j.stem.2015.05.001

Abstract

Imperfect purity, subtypes, and retrospective functional assays compromise efforts to define the molecular identity of hematopoietic stem cells (HSCs). In this issue of Cell Stem Cell, Wilson et al. (2015) use a single-cell-based bioinformatics-experimental strategy to extract a consensus molecular signature from heterogeneous HSC pools. Their data and strategy provide a powerful resource for stem cell characterization.

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MeSH terms

Animals
Gene Expression Regulation*
Hematopoietic Stem Cells / cytology*
Hematopoietic Stem Cells / metabolism*
Humans
Single-Cell Analysis / methods*