Abstract
The combination treatment of hormone-dependent autochthonous mammary carcinomas in the rat with nicotine plus HECNU, a water-soluble nitrosourea, resulted in a potentiation of antitumor action. Nicotine and its metabolite cotinine are strong inhibitors of the aromatase. With regard to investigations in smoking women, suggesting a decreased endogenous estrogen production, our results indicate that smoking might influence growth and treatment results of hormone-dependent human cancer.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Aromatase / metabolism
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Chemical Phenomena
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Chemistry
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Drug Synergism
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Estrogens / metabolism*
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Estrogens / pharmacology
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Female
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Humans
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Mammary Neoplasms, Experimental / drug therapy
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Mammary Neoplasms, Experimental / metabolism*
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Mammary Neoplasms, Experimental / pathology
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Microsomes / drug effects
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Microsomes / enzymology
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Neoplasms, Hormone-Dependent / drug therapy
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Neoplasms, Hormone-Dependent / metabolism*
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Neoplasms, Hormone-Dependent / pathology
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Nicotine / metabolism
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Nicotine / pharmacology*
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Rats
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Smoking / metabolism*
Substances
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Estrogens
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Nicotine
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Aromatase