Hepatitis B Virus Reactivation During Successful Treatment of Hepatitis C Virus With Sofosbuvir and Simeprevir

Clin Infect Dis. 2015 Oct 15;61(8):1304-6. doi: 10.1093/cid/civ474. Epub 2015 Jun 16.

Abstract

Treatment of hepatitis C virus with potent, interferon-free, direct-acting antiviral regimens with no activity against hepatitis B virus (HBV) may increase the risk for HBV reactivation in coinfected patients. We present 2 cases of HBV reactivation during treatment with an all-oral regimen of simeprevir and sofosbuvir and discuss strategies to prevent HBV flare.

Keywords: HBV reactivation; HBV/HCV coinfection; acute hepatitis; simeprevir; sofosbuvir.

Publication types

  • Case Reports

MeSH terms

  • Administration, Oral
  • Antiviral Agents / administration & dosage
  • Antiviral Agents / therapeutic use*
  • Coinfection*
  • Drug Therapy, Combination
  • Hepatitis B / complications*
  • Hepatitis B / virology
  • Hepatitis B virus / physiology*
  • Hepatitis C, Chronic / complications*
  • Hepatitis C, Chronic / drug therapy*
  • Hepatitis C, Chronic / virology
  • Humans
  • Male
  • Middle Aged
  • Risk Factors
  • Simeprevir / administration & dosage
  • Simeprevir / therapeutic use*
  • Sofosbuvir / administration & dosage
  • Sofosbuvir / therapeutic use*

Substances

  • Antiviral Agents
  • Simeprevir
  • Sofosbuvir