Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression

Rita Nahta; Fahd Al-Mulla; Rabeah Al-Temaimi; Amedeo Amedei; Rafaela Andrade-Vieira; Sarah N Bay; Dustin G Brown; Gloria M Calaf; Robert C Castellino; Karine A Cohen-Solal; Annamaria Colacci; Nichola Cruickshanks; Paul Dent; Riccardo Di Fiore; Stefano Forte; Gary S Goldberg; Roslida A Hamid; Harini Krishnan; Dale W Laird; Ahmed Lasfar; Paola A Marignani; Lorenzo Memeo; Chiara Mondello; Christian C Naus; Richard Ponce-Cusi; Jayadev Raju; Debasish Roy; Rabindra Roy; Elizabeth P Ryan; Hosni K Salem; A Ivana Scovassi; Neetu Singh; Monica Vaccari; Renza Vento; Jan Vondráček; Mark Wade; Jordan Woodrick; William H Bisson

doi:10.1093/carcin/bgv028

Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression

Carcinogenesis. 2015 Jun;36 Suppl 1(Suppl 1):S2-18. doi: 10.1093/carcin/bgv028.

Authors

Rita Nahta¹, Fahd Al-Mulla², Rabeah Al-Temaimi², Amedeo Amedei³, Rafaela Andrade-Vieira⁴, Sarah N Bay⁵, Dustin G Brown⁶, Gloria M Calaf⁷, Robert C Castellino⁸, Karine A Cohen-Solal⁹, Annamaria Colacci¹⁰, Nichola Cruickshanks¹¹, Paul Dent¹¹, Riccardo Di Fiore¹², Stefano Forte¹³, Gary S Goldberg¹⁴, Roslida A Hamid¹⁵, Harini Krishnan¹⁴, Dale W Laird¹⁶, Ahmed Lasfar¹⁷, Paola A Marignani⁴, Lorenzo Memeo¹³, Chiara Mondello¹⁸, Christian C Naus¹⁹, Richard Ponce-Cusi²⁰, Jayadev Raju²¹, Debasish Roy²², Rabindra Roy²³, Elizabeth P Ryan⁶, Hosni K Salem²⁴, A Ivana Scovassi¹⁸, Neetu Singh²⁵, Monica Vaccari¹⁰, Renza Vento²⁶, Jan Vondráček²⁷, Mark Wade²⁸, Jordan Woodrick²³, William H Bisson²⁹

Affiliations

¹ Departments of Pharmacology and Hematology & Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, GA 30322, USA, Department of Pathology, Kuwait University, Safat 13110, Kuwait, Department of Experimental and Clinical Medicine, University of Firenze, 50134 Florence, Italy, Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada, Program in Genetics and Molecular Biology, Graduate Division of Biological and Biomedical Sciences, Emory University, Atlanta, GA 30322, USA, Department of Environmental and Radiological Health Sciences/Colorado State University/Colorado School of Public Health, Fort Collins, CO 80523-1680, USA, Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA, Instituto de Alta Investigacion, Universidad de Tarapaca, Arica 8097877, Chile, Division of Hematology and Oncology, Department of Pediatrics, Children's Healthcare of Atlanta and Emory University, Atlanta, GA 30322, USA, Department of Medicine/Medical Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08901-1914, USA, Center for Environmental Carcinogenesis and Risk Assessment, Environmental Protection and Health Prevention Agency, Bologna 40126, Italy, Departments of Neurosurgery and Biochemistry and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 980033, USA, Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies, Polyclinic Plexus, University of Palermo, 90127 Palermo, Italy, Mediterranean Institute of Oncology, 95029 Viagrande, Italy, Graduate School of Biomedical Sciences and Department of Molecular Biology, School of Osteopathic Medicine, Rowan University, Stratford, NJ 08084-1501, USA, Department of Biomedical Science, Faculty of Medicine and Health Sciences, University Putra, Serdang, Selangor 43400, Malaysia, Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontari
² Department of Pathology, Kuwait University, Safat 13110, Kuwait.
³ Department of Experimental and Clinical Medicine, University of Firenze, 50134 Florence, Italy.
⁴ Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada.
⁵ Program in Genetics and Molecular Biology, Graduate Division of Biological and Biomedical Sciences, Emory University, Atlanta, GA 30322, USA.
⁶ Department of Environmental and Radiological Health Sciences/Colorado State University/Colorado School of Public Health, Fort Collins, CO 80523-1680, USA.
⁷ Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA, Instituto de Alta Investigacion, Universidad de Tarapaca, Arica 8097877, Chile.
⁸ Division of Hematology and Oncology, Department of Pediatrics, Children's Healthcare of Atlanta and Emory University, Atlanta, GA 30322, USA.
⁹ Department of Medicine/Medical Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08901-1914, USA.
¹⁰ Center for Environmental Carcinogenesis and Risk Assessment, Environmental Protection and Health Prevention Agency, Bologna 40126, Italy.
¹¹ Departments of Neurosurgery and Biochemistry and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 980033, USA.
¹² Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies, Polyclinic Plexus, University of Palermo, 90127 Palermo, Italy.
¹³ Mediterranean Institute of Oncology, 95029 Viagrande, Italy.
¹⁴ Graduate School of Biomedical Sciences and Department of Molecular Biology, School of Osteopathic Medicine, Rowan University, Stratford, NJ 08084-1501, USA.
¹⁵ Department of Biomedical Science, Faculty of Medicine and Health Sciences, University Putra, Serdang, Selangor 43400, Malaysia.
¹⁶ Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario N6A 5C1, Canada.
¹⁷ Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, NJ 60503, USA.
¹⁸ Institute of Molecular Genetics, National Research Council, 27100 Pavia, Italy.
¹⁹ Department of Cellular & Physiological Sciences, Life Sciences Institute, Faculty of Medicine, The University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
²⁰ Instituto de Alta Investigacion, Universidad de Tarapaca, Arica 8097877, Chile.
²¹ Toxicology Research Division, Bureau of Chemical Safety Food Directorate, Health Products and Food Branch Health Canada, Ottawa, Ontario K1A0K9, Canada.
²² Department of Natural Science, The City University of New York at Hostos Campus, Bronx, NY 10451, USA.
²³ Molecular Oncology Program, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington DC 20057, USA.
²⁴ Urology Dept., kasr Al-Ainy School of Medicine, Cairo University, El Manial, Cairo 12515, Egypt.
²⁵ Advanced Molecular Science Research Centre, King George's Medical University, Lucknow, UP 226003, India.
²⁶ Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies, Polyclinic Plexus, University of Palermo, 90127 Palermo, Italy, Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA.
²⁷ Department of Cytokinetics, Institute of Biophysics AS CR, Brno 612 65, Czech Republic.
²⁸ Center for Genomic Science of IIT@SEMM, Istituto Italiano di Tecnologia (IIT), Milan 16163, Italy and.
²⁹ Environmental and Molecular Toxicology, Environmental Health Sciences Center, Oregon State University, Corvallis, OR 97331, USA.

Abstract

As part of the Halifax Project, this review brings attention to the potential effects of environmental chemicals on important molecular and cellular regulators of the cancer hallmark of evading growth suppression. Specifically, we review the mechanisms by which cancer cells escape the growth-inhibitory signals of p53, retinoblastoma protein, transforming growth factor-beta, gap junctions and contact inhibition. We discuss the effects of selected environmental chemicals on these mechanisms of growth inhibition and cross-reference the effects of these chemicals in other classical cancer hallmarks.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Environmental Exposure / adverse effects*
Hazardous Substances / adverse effects*
Humans
Neoplasms / chemically induced*
Neoplasms / etiology*
Signal Transduction / drug effects

Substances

Hazardous Substances

Abstract

Publication types

MeSH terms

Substances

Grants and funding