Mathematical Models of Quasi-Species Theory and Exact Results for the Dynamics

Curr Top Microbiol Immunol. 2016:392:121-39. doi: 10.1007/82_2015_471.

Abstract

We formulate the Crow-Kimura, discrete-time Eigen model, and continuous-time Eigen model. These models are interrelated and we established an exact mapping between them. We consider the evolutionary dynamics for the single-peak fitness and symmetric smooth fitness. We applied the quantum mechanical methods to find the exact dynamics of the evolution model with a single-peak fitness. For the smooth symmetric fitness landscape, we map exactly the evolution equations into Hamilton-Jacobi equation (HJE). We apply the method to the Crow-Kimura (parallel) and Eigen models. We get simple formulas to calculate the dynamics of the maximum of distribution and the variance. We review the existing mathematical tools of quasi-species theory.

Publication types

  • Review

MeSH terms

  • Evolution, Molecular*
  • Models, Genetic
  • Models, Theoretical*
  • Mutation