Local increase in interleukin-1-like activity following UVB irradiation of human skin in vivo

Photodermatol. 1989 Dec;6(6):268-74.

Abstract

Using an in vivo skin chamber method, we demonstrated increased release of interleukin-1 (IL-1)-like activity at the site of irradiation with 3 times the minimal erythema dose of ultraviolet B (UVB). IL-1-like activity was estimated using the mouse thymocyte amplification assay. UVB-augmented release of IL-1-like activity peaked 1 h after irradiation and levels returned to baseline by 2 h. Release of IL-1-like activity from human skin after exposure to UV radiation may account for some of the local and systemic features of the sunburn response.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Animals
  • Dose-Response Relationship, Radiation
  • Female
  • Humans
  • Interleukin-1 / metabolism*
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred CBA
  • Skin / radiation effects*
  • Sunburn / etiology*
  • Time Factors
  • Ultraviolet Rays*

Substances

  • Interleukin-1