Knockdown of either filaggrin or loricrin increases the productions of interleukin (IL)-1α, IL-8, IL-18 and granulocyte macrophage colony-stimulating factor in stratified human keratinocytes

J Dermatol Sci. 2015 Nov;80(2):158-60. doi: 10.1016/j.jdermsci.2015.09.002. Epub 2015 Sep 7.

Authors

Takashi Sakai¹, Yutaka Hatano², Wei Zhang¹, Sakuhei Fujiwara¹, Ryo Nishiyori³

Affiliations

¹ Department of Dermatology, Faculty of Medicine, Oita University, Oita, Japan.
² Department of Dermatology, Faculty of Medicine, Oita University, Oita, Japan. Electronic address: hatano@oita-u.ac.jp.
³ Medical student, Faculty of Medicine, Oita University, Oita, Japan.

PMID: 26381575
DOI: 10.1016/j.jdermsci.2015.09.002

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Cells, Cultured
Down-Regulation
Filaggrin Proteins
Gene Knockdown Techniques*
Granulocyte Colony-Stimulating Factor / metabolism*
Humans
Interleukin-18 / metabolism*
Interleukin-1alpha / metabolism*
Interleukin-8 / metabolism*
Intermediate Filament Proteins / genetics
Intermediate Filament Proteins / metabolism*
Keratinocytes / immunology
Keratinocytes / metabolism*
Membrane Proteins / genetics
Membrane Proteins / metabolism*
RNA Interference
Transfection
Up-Regulation

Substances

CXCL8 protein, human
FLG protein, human
Filaggrin Proteins
IL1A protein, human
Interleukin-18
Interleukin-1alpha
Interleukin-8
Intermediate Filament Proteins
Membrane Proteins
loricrin
Granulocyte Colony-Stimulating Factor