Breast cancer following spinal irradiation for a childhood cancer: A report from the Childhood Cancer Survivor Study

Radiother Oncol. 2015 Nov;117(2):213-6. doi: 10.1016/j.radonc.2015.09.016. Epub 2015 Sep 18.

Abstract

It has been suggested that pediatric patients treated with spinal irradiation may have an elevated risk of breast cancer. Among a cohort of 363 long-term survivors of a pediatric central nervous system tumor or leukemia treated with spinal irradiation, there was little evidence of an increased breast cancer risk.

Keywords: Craniospinal irradiation; Late effects; Secondary breast cancer.

Publication types

  • Multicenter Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Breast Neoplasms / epidemiology
  • Breast Neoplasms / etiology*
  • Central Nervous System Neoplasms / epidemiology
  • Central Nervous System Neoplasms / radiotherapy*
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Leukemia / epidemiology
  • Leukemia / radiotherapy*
  • Neoplasms, Radiation-Induced / epidemiology
  • Neoplasms, Radiation-Induced / etiology*
  • Neoplasms, Second Primary / epidemiology
  • Neoplasms, Second Primary / etiology*
  • Radiotherapy Dosage
  • Risk
  • Survivors
  • United States / epidemiology