Mitochondrial heat-shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondria

M Y Cheng; F U Hartl; J Martin; R A Pollock; F Kalousek; W Neupert; E M Hallberg; R L Hallberg; A L Horwich

doi:10.1038/337620a0

Mitochondrial heat-shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondria

Nature. 1989 Feb 16;337(6208):620-5. doi: 10.1038/337620a0.

Authors

M Y Cheng¹, F U Hartl, J Martin, R A Pollock, F Kalousek, W Neupert, E M Hallberg, R L Hallberg, A L Horwich

Affiliation

¹ Yale University School of Medicine, Department of Human Genetics, New Haven, Connecticut 06510.

PMID: 2645524
DOI: 10.1038/337620a0

Abstract

A nuclear encoded mitochondrial heat-shock protein hsp60 is required for the assembly into oligomeric complexes of proteins imported into the mitochondrial matrix. hsp60 is a member of the 'chaperonin' class of protein factors, which include the Escherichia coli groEL protein and the Rubisco subunit-binding protein of chloroplasts.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Fungal Proteins / genetics*
Genes
Genes, Fungal
Heat-Shock Proteins / genetics
Heat-Shock Proteins / physiology*
Mitochondria / metabolism*
Mutation
Plasmids
Protein Processing, Post-Translational*
Saccharomyces cerevisiae / genetics*
Saccharomyces cerevisiae / metabolism

Substances

Fungal Proteins
Heat-Shock Proteins