A Rare Cause of Reversible Renal Hemosiderosis

Rima Abou Arkoub; Don Wang; Deborah Zimmerman

doi:10.1155/2015/464059

A Rare Cause of Reversible Renal Hemosiderosis

Case Rep Nephrol. 2015:2015:464059. doi: 10.1155/2015/464059. Epub 2015 Sep 30.

Authors

Rima Abou Arkoub¹, Don Wang², Deborah Zimmerman³

Affiliations

¹ Division of nephrology, The Ottawa Hospital, Ottawa, ON, Canada K1H 7W9.
² Division of Anatomical Pathology, Department of Pathology and Laboratory Medicine, The Ottawa Hospital and Kidney Research Centre of the Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada K1H 7W9.
³ Division of Nephrology, The Ottawa Hospital and University of Ottawa, Ottawa, ON, Canada K1H 7W9.

Abstract

Kidney failure secondary to renal hemosiderosis has been reported in diseases with intravascular hemolysis, like paroxysmal nocturnal hemoglobinuria, and valvular heart diseases. We present here a case of hemosiderin induced acute tubular necrosis secondary to intravascular hemolysis from Clostridium difficile infection with possible role of supratherapeutic INR. We discuss the pathophysiology, causes, and prognosis of acute tubular injury from hemosiderosis.