Abstract
A new series of vinca-alkaloids derivatives containing various α,β-unsaturated aromatic side chains was synthesized. Four new vinca-alkaloids derivatives showed selective cytotoxicities against KB tumor cell lines with IC50 value below 0.1 μM, thus comparable with vinblastine.
Keywords:
Cytotoxicity; Sarcodictyins; Tubulin; Vinca alkaloids.
Copyright © 2015 Elsevier Ltd. All rights reserved.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemical synthesis*
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / therapeutic use*
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Cell Line, Tumor
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Humans
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Inhibitory Concentration 50
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Molecular Structure
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Neoplasms / drug therapy*
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Vinblastine / chemistry
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Vinblastine / therapeutic use*
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Vinca Alkaloids / chemistry
Substances
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Antineoplastic Agents, Phytogenic
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Vinca Alkaloids
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Vinblastine