Abstract
This clinical trial investigated the impact of a six-week supplementation with fish oil and single nucleotide polymorphisms (SNPs) in PLA2G4A and PLA2G6 genes on total omega-6 fatty acid (n-6 FA) levels in plasma phospholipids (PL) and plasma C-reactive protein (CRP) levels in 191 subjects. Interaction effects between SNPs and supplementation modulated total n-6 FAs and CRP levels in both men and women. Associations between SNPs and total n-6 FA levels and between SNPs and CRP levels were identified in men, independently of supplementation. Supplementation decreased total n-6 FAs without affecting plasma CRP levels. Changes in CRP levels correlated positively with changes in total n-6 FAs in men (r=0.25 p=0.01), but not in women. In conclusion, total n-6 FA levels in plasma PL and plasma CRP levels are modulated by SNPs within PLA2G4A and PLA2G6 genes alone or in combination with fish oil supplementation.
Keywords:
C-reactive protein; Gene-diet interaction; Inflammation; Omega-3 fatty acid; Omega-6 fatty acid; Phospholipase A2.
Copyright © 2015 Elsevier Ltd. All rights reserved.
Publication types
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Controlled Clinical Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
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Anti-Inflammatory Agents, Non-Steroidal / metabolism
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Body Mass Index
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C-Reactive Protein / analysis*
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Dietary Supplements*
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Fatty Acids, Omega-6 / administration & dosage
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Fatty Acids, Omega-6 / analysis
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Fatty Acids, Omega-6 / antagonists & inhibitors
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Fatty Acids, Omega-6 / blood*
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Female
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Fish Oils / administration & dosage*
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Fish Oils / metabolism
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Genetic Association Studies
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Group IV Phospholipases A2 / genetics*
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Group IV Phospholipases A2 / metabolism
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Group VI Phospholipases A2 / genetics*
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Group VI Phospholipases A2 / metabolism
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Humans
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Male
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Middle Aged
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Nutrigenomics / methods
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Overweight / blood
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Overweight / genetics
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Overweight / metabolism
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Phospholipids / blood
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Phospholipids / chemistry
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Polymorphism, Single Nucleotide*
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Quebec
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Sex Characteristics
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Young Adult
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Fatty Acids, Omega-6
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Fish Oils
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Phospholipids
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C-Reactive Protein
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Group IV Phospholipases A2
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Group VI Phospholipases A2
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PLA2G4A protein, human
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PLA2G6 protein, human