Mechanisms of Stress Resistance and Gene Regulation in the Radioresistant Bacterium Deinococcus radiodurans

A A Agapov; A V Kulbachinskiy

doi:10.1134/S0006297915100016

Mechanisms of Stress Resistance and Gene Regulation in the Radioresistant Bacterium Deinococcus radiodurans

Biochemistry (Mosc). 2015 Oct;80(10):1201-16. doi: 10.1134/S0006297915100016.

Authors

A A Agapov¹, A V Kulbachinskiy

Affiliation

¹ Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, 123182, Russia. akulb@img.ras.ru.

PMID: 26567564
DOI: 10.1134/S0006297915100016

Abstract

The bacterium Deinococcus radiodurans reveals extraordinary resistance to ionizing radiation, oxidative stress, desiccation, and other damaging conditions. In this review, we consider the main molecular mechanisms underlying such resistance, including the action of specific DNA repair and antioxidation systems, and transcription regulation during the anti-stress response.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Cell Wall / radiation effects
DNA Repair / radiation effects
Deinococcus / cytology
Deinococcus / genetics*
Deinococcus / metabolism*
Deinococcus / radiation effects
Gene Expression Regulation, Bacterial / radiation effects*
Oxidative Stress / genetics
Oxidative Stress / radiation effects*
Radiation Tolerance*