Early Guillain-Barré Syndrome associated with acute dengue fever

O Simon; S Billot; D Guyon; M Daures; E Descloux; A C Gourinat; N Molko; M Dupont-Rouzeyrol

doi:10.1016/j.jcv.2016.01.016

Early Guillain-Barré Syndrome associated with acute dengue fever

J Clin Virol. 2016 Apr:77:29-31. doi: 10.1016/j.jcv.2016.01.016. Epub 2016 Feb 3.

Authors

O Simon¹, S Billot², D Guyon², M Daures³, E Descloux⁴, A C Gourinat⁵, N Molko², M Dupont-Rouzeyrol⁶

Affiliations

¹ Department of Neurology, Territorial Hospital, Noumea, New Caledonia. Electronic address: o.simon@cht.nc.
² Department of Neurology, Territorial Hospital, Noumea, New Caledonia.
³ New Caledonia Health Department, Noumea, New Caledonia.
⁴ Department of Internal Medicine and Infectious Diseases, Territorial Hospital, Noumea, New Caledonia.
⁵ Immuno-Serology and Molecular Biology Lab, Institut Pasteur in New Caledonia, Institut Pasteur International Network, Noumea, New Caledonia.
⁶ Dengue and Arboviruses Expertise and Research Unit, Institut Pasteur in New Caledonia, Institut Pasteur International Network, Noumea, New Caledonia.

PMID: 26895226
DOI: 10.1016/j.jcv.2016.01.016

Abstract

Various forms of neurological manifestations are reported in dengue fever. We describe here three cases of concomitant Guillain-Barré syndrome and dengue virus (DENV) infection during the largest DENV-1 outbreak in New Caledonia. Research of viral RNA was positive in both blood and CSF samples. All patients were treated with intravenous polyvalent immunoglobulins and recovered without sequelae within one week.

Keywords: Acute; Dengue; Guillain–Barré Syndrome; Infectious disease; Neurology.

Publication types

Case Reports
Review

MeSH terms

Aged
Dengue / complications*
Dengue / diagnosis*
Dengue Virus / genetics
Female
Guillain-Barre Syndrome / complications*
Guillain-Barre Syndrome / diagnosis*
Humans
Male
Middle Aged
Polymerase Chain Reaction
RNA, Viral

Substances

RNA, Viral