Regulation of SIRT1 in aging: Roles in mitochondrial function and biogenesis

Yujia Yuan; Vinicius Fernandes Cruzat; Philip Newsholme; Jingqiu Cheng; Younan Chen; Yanrong Lu

doi:10.1016/j.mad.2016.02.003

Regulation of SIRT1 in aging: Roles in mitochondrial function and biogenesis

Mech Ageing Dev. 2016 Apr:155:10-21. doi: 10.1016/j.mad.2016.02.003. Epub 2016 Mar 7.

Authors

Yujia Yuan¹, Vinicius Fernandes Cruzat², Philip Newsholme³, Jingqiu Cheng¹, Younan Chen⁴, Yanrong Lu⁵

Affiliations

¹ Key Laboratory of Transplant Engineering and Immunology, NHFPC, Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, PR China.
² School of Biomedical Sciences, CHIRI Biosciences, Curtin University, GPO Box U1987, Perth, Western Australia, Australia; Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, Brazil.
³ School of Biomedical Sciences, CHIRI Biosciences, Curtin University, GPO Box U1987, Perth, Western Australia, Australia.
⁴ Key Laboratory of Transplant Engineering and Immunology, NHFPC, Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, PR China; School of Biomedical Sciences, CHIRI Biosciences, Curtin University, GPO Box U1987, Perth, Western Australia, Australia. Electronic address: chenyounan@scu.edu.cn.
⁵ Key Laboratory of Transplant Engineering and Immunology, NHFPC, Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, PR China. Electronic address: luyanrong@scu.edu.cn.

PMID: 26923269
DOI: 10.1016/j.mad.2016.02.003

Abstract

Aging is a degenerative process associated with cumulative damage, which leads to cellular dysfunction, tissue failure, and disorders of body function. Silent information regulator-1, also known as sirtuin 1 (SIRT1), has been reported to be involved in the regulation of various important biological processes, including inflammation, mitochondrial biogenesis, as well as cell senescence and consequent aging. The level of SIRT1 is decreased in both transcriptional and postranscriptional conditions during aging, accompanied by attenuated mitochondrial biogenesis, an important component of aging-related diseases. Over the last decade, extensive studies have demonstrated that SIRT1 can activate several transcriptional factors, such as peroxisome proliferator activated receptor γ co-activator 1α (PGC-1α) and hypoxia-inducible factor 1α (HIF-1α) resulting in ameliorated mitochondria biogenesis and extended life span. In this review, we focus on the molecular regulation of SIRT1 and its role in mitochondrial biogenesis during in the context of aging and aging-related diseases.

Keywords: HIF-1α; Oxidative phosphorylation; PGC-1α; Reactive oxygen species.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Aging / genetics
Aging / metabolism*
Animals
Cellular Senescence / genetics
Humans
Hypoxia-Inducible Factor 1, alpha Subunit / genetics
Hypoxia-Inducible Factor 1, alpha Subunit / metabolism
Mitochondria / genetics
Mitochondria / metabolism*
Mitochondrial Dynamics*
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / genetics
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / metabolism
Sirtuin 1 / genetics
Sirtuin 1 / metabolism*

Substances

HIF1A protein, human
Hypoxia-Inducible Factor 1, alpha Subunit
PPARGC1A protein, human
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
SIRT1 protein, human
Sirtuin 1