Combinatorial Antigen Targeting: Ideal T-Cell Sensing and Anti-Tumor Response

Maria Themeli; Michel Sadelain

doi:10.1016/j.molmed.2016.02.009

Combinatorial Antigen Targeting: Ideal T-Cell Sensing and Anti-Tumor Response

Trends Mol Med. 2016 Apr;22(4):271-273. doi: 10.1016/j.molmed.2016.02.009. Epub 2016 Mar 10.

Authors

Maria Themeli¹, Michel Sadelain²

Affiliations

¹ Department of Hematology, VU University Medical Center, Cancer Center Amsterdam, 1081 HV, Amsterdam, The Netherlands.
² Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Immunology Program, Memorial Sloan Kettering Institute, New York, NY 10065, USA. Electronic address: m-sadelain@ski.mskcc.org.

Abstract

T cells expressing chimeric antigen receptors (CARs) are a formidable platform for the study and application of synthetic biology approaches to study customized and flexible control of cellular functions. Recent reports in the journal Cell provide a new twist on combinatorial antigen targeting, profiting from the singular cleavage and signaling of the Notch receptor to conditionally express CARs.

Publication types

Comment

MeSH terms

Animals
Cell Engineering*
Humans
Immunotherapy / methods*
Neoplasms / immunology*
Neoplasms / therapy*
Receptors, Notch / chemistry*
Signal Transduction*
Synthetic Biology / methods*
T-Lymphocytes / metabolism*

Substances

Receptors, Notch

Grants and funding

P30 CA008748/CA/NCI NIH HHS/United States