Allergen immunotherapy for allergic rhinoconjunctivitis: protocol for a systematic review

Sangeeta Dhami; Ulugbek Nurmatov; Graham Roberts; Oliver Pfaar; Antonella Muraro; Ignacio J Ansotegui; Moises Calderon; Cemal Cingi; Pascal Demoly; Stephen Durham; Ronald Gerth van Wijk; Susanne Halken; Eckard Hamelmann; Peter Hellings; Lars Jacobsen; Edward Knol; Desiree Larenas-Linnemann; Sandra Lin; Vivian Maggina; Hanneke Oude-Elberink; Giovanni Pajno; Ruby Panwankar; Elideanna Pastorello; Constantinos Pitsios; Giuseppina Rotiroti; Frans Timmermans; Olympia Tsilochristou; Eva-Maria Varga; Jamie Wilkinson; Andrew Williams; Margitta Worm; Luo Zhang; Aziz Sheikh

doi:10.1186/s13601-016-0099-6

Allergen immunotherapy for allergic rhinoconjunctivitis: protocol for a systematic review

Clin Transl Allergy. 2016 Mar 22:6:12. doi: 10.1186/s13601-016-0099-6. eCollection 2016.

Authors

Sangeeta Dhami¹, Ulugbek Nurmatov², Graham Roberts³, Oliver Pfaar⁴, Antonella Muraro⁵, Ignacio J Ansotegui⁶, Moises Calderon⁷, Cemal Cingi⁸, Pascal Demoly⁹, Stephen Durham⁷, Ronald Gerth van Wijk¹⁰, Susanne Halken¹¹, Eckard Hamelmann¹², Peter Hellings¹³, Lars Jacobsen¹⁴, Edward Knol¹⁵, Desiree Larenas-Linnemann¹⁶, Sandra Lin¹⁷, Vivian Maggina¹⁸, Hanneke Oude-Elberink¹⁹, Giovanni Pajno²⁰, Ruby Panwankar²¹, Elideanna Pastorello²², Constantinos Pitsios²³, Giuseppina Rotiroti²⁴, Frans Timmermans²⁵, Olympia Tsilochristou²⁶, Eva-Maria Varga²⁷, Jamie Wilkinson²⁸, Andrew Williams²⁹, Margitta Worm³⁰, Luo Zhang³¹, Aziz Sheikh³²

Affiliations

¹ Evidence-Based Health Care Ltd, Edinburgh, UK.
² Systematic Review at Decision Resources Group Abacus International, Bicester, UK.
³ The David Hide Asthma and Allergy Research Centre, St Mary's Hospital, Newport Isle of Wight, NIHR Respiratory Biomedical Research Unit, University Hospital Southampton NHS Foundation Trust, University of Southampton, Southampton, UK ; Faculty of Medicine, University of Southampton, Southampton, UK.
⁴ Department of Otorhinolaryngology, Head and Neck Surgery University Hospital, Mannheim and Center for Rhinology and Allergology, Wiesbaden, Germany.
⁵ Food Allergy Referral Centre Veneto Region, Department of Women and Child Health, Padua General University Hospital, Padua, Italy.
⁶ Hospital Quiron Bizkair, Bilbao, Spain.
⁷ National Heart and Lung Institute, Imperial College, London, UK.
⁸ Department of ENT, Eskisehir Osmangazi University Medical Faculty, Eskisehir, Turkey.
⁹ University and Hospital of Montpellier, Inserm Paris Sorbonnes, Montpellier, France.
¹⁰ Section of Allergology, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
¹¹ Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark.
¹² Children's Center Bethel, EvKB, Bieledelf and Allergy Center Buhr-University, Bochum, Germany.
¹³ Laboratory of Experimental Immunology, University Hospitals Leuven, Louvain, Belgium.
¹⁴ ALC, Allergy Learning and Consulting, Copenhagen, Denmark.
¹⁵ University Medical Center, Utrecht, The Netherlands.
¹⁶ Hospital Medica Sur, Mexico City, Mexico.
¹⁷ Department of Otolaryngology-Head and Neck Surgery, John Hopkins, Baltimore, USA.
¹⁸ Allergy and Clinical Immunology Unit, 2nd Department of Pediatrics, University of Athens, P and A Kiriakou Children's Hospital, Athens, Greece.
¹⁹ Department of Allergology, Groningen Research Institute for Asthma and COPD (GRIAC), University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
²⁰ Department of Pediatrics, University of Messina, Messina, Italy.
²¹ Department of Pediatrics, Nippon Medical School, Tokyo, Japan.
²² University of Milano, Milan, Italy.
²³ Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
²⁴ The Royal National Throat, Nose and Ear Hospital, University College London, London, UK.
²⁵ Netherlands Anafylaxis Network, Dordrecht, The Netherlands.
²⁶ Charite University Hospital, Berlin, Germany.
²⁷ Dept. of Paediatrics, Respiratory and Allergic Disease Division, Medical University Graz, Graz, Austria.
²⁸ Pharmaceutical Group of the European Union, Brussels, Belgium.
²⁹ Guy's and St Thomas' NHS Foundation Trust, London, UK.
³⁰ Chartie-Universitatsmedizin, Berlin, Germany.
³¹ Beijing Institute of Otolarygology, Beijing, China.
³² Allergy and Respiratory Research Group, The University of Edinburgh, Edinburgh, UK.

Abstract

Background: The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines for Allergen Immunotherapy (AIT) for the Management of Allergic Rhinoconjunctivitis. We seek to critically assess the effectiveness, cost-effectiveness and safety of AIT in the management of allergic rhinoconjunctivitis.

Methods: We will undertake a systematic review, which will involve searching international biomedical databases for published, in progress and unpublished evidence. Studies will be independently screened against pre-defined eligibility criteria and critically appraised using established instruments. Data will be descriptively and, if possible and appropriate, quantitatively synthesised.

Conclusion: The findings from this review will be used to inform the development of recommendations for EAACI's Guidelines on AIT.

Keywords: Allergen immunotherapy; Allergic rhinoconjunctivitis; Allergy; Rhinitis.