Zika virus: epidemiology, clinical features and host-virus interactions

Rodolphe Hamel; Florian Liégeois; Sineewanlaya Wichit; Julien Pompon; Fodé Diop; Loïc Talignani; Frédéric Thomas; Philippe Desprès; Hans Yssel; Dorothée Missé

doi:10.1016/j.micinf.2016.03.009

Zika virus: epidemiology, clinical features and host-virus interactions

Microbes Infect. 2016 Jul-Aug;18(7-8):441-9. doi: 10.1016/j.micinf.2016.03.009. Epub 2016 Mar 22.

Affiliations

¹ Laboratoire MIVEGEC, UMR 224 IRD/CNRS/UM1, Montpellier, France.
² Laboratoire MIVEGEC, UMR 224 IRD/CNRS/UM1, Montpellier, France; Programme in Emerging Infectious Disease, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore.
³ UM 134 PIMIT, Université de La Réunion, Inserm U1187, CNRS 9192, IRD 249, GIP-CYROI, 97491 Saint Clotilde, La Réunion, France.
⁴ Centre d'Immunologie et des Maladies Infectieuses, Inserm, U1135, Sorbonne Universités, UPMC, APHP Hôpital Pitié-Salpêtrière, Paris, France.
⁵ Laboratoire MIVEGEC, UMR 224 IRD/CNRS/UM1, Montpellier, France. Electronic address: dorothee.misse@ird.fr.

PMID: 27012221
DOI: 10.1016/j.micinf.2016.03.009

Abstract

Very recently, Zika virus (ZIKV) has gained a medical importance following the large-scale epidemics in South Pacific and Latin America. This paper reviews information on the epidemiology and clinical features of Zika disease with a particular emphasis on the host-virus interactions that contribute to the pathogenicity of ZIKV in humans.

Keywords: Arbovirus; Epidemiology; Host-pathogen interactions; Innate immunity; Vector; ZIKA.

Publication types

Review

MeSH terms

Host-Pathogen Interactions*
Humans
Latin America / epidemiology
Pacific Islands / epidemiology
Zika Virus / pathogenicity*
Zika Virus Infection / epidemiology*
Zika Virus Infection / pathology*
Zika Virus Infection / virology