We describe a case of voluntary intoxication with tricyclic antidepressant drugs: initial electrocardiogram showed alterations of atrial repolarization (Ta segment) which were more pronounced than usual ST-T alterations. Evolution was uneventful (and repolarization normalized). Tricyclic antidepressant drugs absorption can lead to Ta segment alterations, which may be a useful clue in the differential diagnosis of drugs intoxication.