International Society of Urological Pathology (ISUP) grading of prostate cancer - An ISUP consensus on contemporary grading

Lars Egevad; Brett Delahunt; John R Srigley; Hemamali Samaratunga

doi:10.1111/apm.12533

International Society of Urological Pathology (ISUP) grading of prostate cancer - An ISUP consensus on contemporary grading

APMIS. 2016 Jun;124(6):433-5. doi: 10.1111/apm.12533.

Authors

Lars Egevad^{1

2}, Brett Delahunt³, John R Srigley⁴, Hemamali Samaratunga⁵

Affiliations

¹ Department of Oncology and Pathology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
² Department of Pathology, Karolinska University Hospital, Stockholm, Sweden.
³ Department of Pathology and Molecular Medicine, Wellington School of Medicine and Health Sciences, University of Otago, Wellington, New Zealand.
⁴ Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
⁵ Aquesta Pathology and University of Queensland School of Medicine, Brisbane, Queensland, Australia.

PMID: 27150257
DOI: 10.1111/apm.12533

Abstract

The International Society of Urological Pathology (ISUP) has issued guidelines for the grading of prostate cancer based on a consensus conference held in 2014. The recommendations resulting from the 2014 consensus conference were a further development of 2005 ISUP modified Gleason grading. In the 2014 system, morphological criteria are clarified, including updated definitions of Gleason pattern 4. In addition to the continued reporting of Gleason scores, we also recommend that Gleason scores ≤6, 3 + 4 = 7, 4 + 3 = 7, 8 and 9-10, respectively, be reported as five groups, i.e. ISUP grades 1-5. This new grading system has the dual benefit of predicting patient outcome as well as facilitating patient communication.

Keywords: Gleason grade; ISUP grade; Prostate cancer; grading.

Publication types

Editorial

MeSH terms

Consensus Development Conferences as Topic
Guidelines as Topic
Humans
Male
Neoplasm Grading / methods*
Neoplasm Grading / standards*
Prostatic Neoplasms / pathology*
Societies, Scientific*