Primary structure and expression from complementary DNA of skeletal muscle ryanodine receptor

Nature. 1989 Jun 8;339(6224):439-45. doi: 10.1038/339439a0.

Abstract

The sequence of 5,037 amino acids composing the ryanodine receptor from rabbit skeletal muscle sarcoplasmic reticulum has been deduced by cloning and sequencing the complementary DNA. The predicted structure suggests that the calcium release channel activity resides in the C-terminal region of the receptor molecule, whereas the remaining portion constitutes the 'foot' structure spanning the junctional gap between the sarcoplasmic reticulum and the transverse tubule.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Calcium Channel Blockers / metabolism
  • Cloning, Molecular
  • DNA / genetics*
  • Molecular Sequence Data
  • Muscles / metabolism*
  • Protein Conformation
  • RNA, Messenger / genetics
  • Rabbits
  • Receptors, Cholinergic / genetics*
  • Receptors, Cholinergic / isolation & purification
  • Restriction Mapping
  • Ryanodine Receptor Calcium Release Channel
  • Sarcoplasmic Reticulum / physiology
  • Sarcoplasmic Reticulum / ultrastructure
  • Transcription, Genetic*

Substances

  • Calcium Channel Blockers
  • RNA, Messenger
  • Receptors, Cholinergic
  • Ryanodine Receptor Calcium Release Channel
  • DNA

Associated data

  • GENBANK/X15209
  • GENBANK/X15749
  • GENBANK/X15750