Identification and derivatization of selected cathinones by spectroscopic studies

Jacek E Nycz; Tadeusz Pazdziorek; Grzegorz Malecki; Marcin Szala

doi:10.1016/j.forsciint.2016.06.034

Identification and derivatization of selected cathinones by spectroscopic studies

Forensic Sci Int. 2016 Sep:266:416-426. doi: 10.1016/j.forsciint.2016.06.034. Epub 2016 Jul 5.

Authors

Jacek E Nycz¹, Tadeusz Pazdziorek², Grzegorz Malecki³, Marcin Szala³

Affiliations

¹ Institute of Chemistry, University of Silesia, ul. Szkolna 9, 40007 Katowice, Poland. Electronic address: jacek.nycz@us.edu.pl.
² Department of Chemistry, Forensic Laboratory, The Regional Headquarters Katowice, Poland.
³ Institute of Chemistry, University of Silesia, ul. Szkolna 9, 40007 Katowice, Poland.

PMID: 27423024
DOI: 10.1016/j.forsciint.2016.06.034

Abstract

In this study we identified three novel hydrochloride salts of cathinones 2-(pyrrolidin-1-yl)-1-(5,6,7,8-tetrahydronaphthalen-2-yl)pentan-1-one (1a) (TH-PVP), 2-(methylamino)-1-(2-methylphenyl)-1-propanone (1b) (2-MMC) and 1-(4-chlorophenyl)-2-(methylamino)propan-1-one (1c) (4-CMC). Their properties have been examined through combinations of GC-MS, IR, NMR, electronic absorption spectroscopy and single crystal X-ray diffraction method. NMR solution spectra showed readily diagnostic H-1 and C-13 signals from methyl, N-methyl and carbonyl groups. Additionally the use of thionation and amination reactions for identification of selected cathinones was presented.

Keywords: Aminoguanidine; Cathinone; Guanidine; Lawesson reagent; P4S10; Thionation.

MeSH terms

Alkaloids / analysis
Alkaloids / chemistry*
Gas Chromatography-Mass Spectrometry*
Magnetic Resonance Spectroscopy*
X-Ray Diffraction

Substances

Alkaloids
cathinone