Abstract
We have synthesized targeted, selective, and highly sensitive (129)Xe NMR nanoscale biosensors using a spherical MS2 viral capsid, Cryptophane A molecules, and DNA aptamers. The biosensors showed strong binding specificity toward targeted lymphoma cells (Ramos line). Hyperpolarized (129)Xe NMR signal contrast and hyper-CEST (129)Xe MRI image contrast indicated its promise as highly sensitive hyperpolarized (129)Xe NMR nanoscale biosensor for future applications in cancer detection in vivo.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, N.I.H., Extramural
MeSH terms
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Aptamers, Nucleotide / chemistry
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Aptamers, Nucleotide / metabolism
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Biosensing Techniques / methods*
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Capsid / chemistry
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Capsid / metabolism
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Cell Line, Tumor
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Humans
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Levivirus
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Magnetic Resonance Spectroscopy
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Models, Molecular
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Molecular Imaging / methods*
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Polycyclic Compounds / chemistry
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Protein Conformation
Substances
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Aptamers, Nucleotide
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Polycyclic Compounds
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cryptophane A