Pharmacological activity of the essential oil of Bupleurum gibraltaricum: anti-inflammatory activity and effects on isolated rat uteri

J Ethnopharmacol. 1989 May;25(3):305-13. doi: 10.1016/0378-8741(89)90036-6.

Abstract

The essential oil of Bupleurum gibraltaricum showed considerable anti-inflammatory activity against carrageenan-produced pedal edema in rats. This appeared to be due to the delta-3-carene component. The essential oil and delta-3-carene both produced qualitatively similar changes in rat uterine contractions caused by oxytocin (a progressive dose-related modification of the concentration-response curves) and acetylcholine (non-progressive modification of the concentration-response curves).

MeSH terms

  • Acetylcholine / pharmacology
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal*
  • Bicyclic Monoterpenes
  • Edema / drug therapy
  • Female
  • In Vitro Techniques
  • Indomethacin / pharmacology
  • Monoterpenes*
  • Oxytocin / pharmacology
  • Plant Oils / pharmacology*
  • Plants, Medicinal*
  • Rats
  • Rats, Inbred Strains
  • Terpenes / pharmacology
  • Uterine Contraction / drug effects*

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Bicyclic Monoterpenes
  • Monoterpenes
  • Plant Oils
  • Terpenes
  • Oxytocin
  • 3-carene
  • Acetylcholine
  • Indomethacin