Abstract
The essential oil of Bupleurum gibraltaricum showed considerable anti-inflammatory activity against carrageenan-produced pedal edema in rats. This appeared to be due to the delta-3-carene component. The essential oil and delta-3-carene both produced qualitatively similar changes in rat uterine contractions caused by oxytocin (a progressive dose-related modification of the concentration-response curves) and acetylcholine (non-progressive modification of the concentration-response curves).
MeSH terms
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Acetylcholine / pharmacology
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Animals
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Anti-Inflammatory Agents, Non-Steroidal*
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Bicyclic Monoterpenes
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Edema / drug therapy
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Female
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In Vitro Techniques
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Indomethacin / pharmacology
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Monoterpenes*
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Oxytocin / pharmacology
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Plant Oils / pharmacology*
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Plants, Medicinal*
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Rats
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Rats, Inbred Strains
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Terpenes / pharmacology
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Uterine Contraction / drug effects*
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Bicyclic Monoterpenes
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Monoterpenes
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Plant Oils
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Terpenes
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Oxytocin
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3-carene
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Acetylcholine
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Indomethacin