Abstract
Endophytic fungi are fungi that colonize internal tissues of plants; several biologically active compounds have been isolated from these fungi. There are few studies of compounds isolated from endophytic fungi of Amazon plants. Thus, this study aimed the isolation and structural identification of ergosterol (1), ergosterol peroxide (2), mevalonolactone (3), cytochalasin B (4) and cytochalasin H (5) from Aspergillus sp. EJC 04, an endophytic fungus from Bauhinia guianensis. The cytochalasin B (4) and the diacetate derivative of cytochalasin B (4a) showed high lethality in the brine shrimp assay. This is the first occurrence of cytochalasins in Amazonian endophytic fungi from B. guianensis.
Keywords:
Artemia salina; Endophytic fungi; Hongos endófitos; Metabolitos secundarios; Secondary metabolites.
Copyright © 2016 Asociación Argentina de Microbiología. Publicado por Elsevier España, S.L.U. All rights reserved.
MeSH terms
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Acetylation
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Animals
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Argentina
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Artemia / drug effects*
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Aspergillus / chemistry*
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Aspergillus / isolation & purification
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Cytochalasin B / chemistry
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Cytochalasin B / isolation & purification
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Cytochalasin B / toxicity*
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Cytochalasins / chemistry
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Cytochalasins / isolation & purification
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Cytochalasins / toxicity*
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Endophytes / chemistry*
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Endophytes / isolation & purification
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Ergosterol / analogs & derivatives*
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Ergosterol / chemistry
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Ergosterol / isolation & purification
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Ergosterol / toxicity
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Fabaceae / microbiology*
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Lethal Dose 50
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Mevalonic Acid / analogs & derivatives*
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Mevalonic Acid / chemistry
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Mevalonic Acid / isolation & purification
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Mevalonic Acid / toxicity
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Spectrometry, Mass, Electrospray Ionization
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Structure-Activity Relationship
Substances
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Cytochalasins
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Cytochalasin B
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cytochalasin H
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mevalonolactone
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Mevalonic Acid
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ergosterol-5,8-peroxide
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Ergosterol