Characterization of the Pathogenesis of H10N3, H10N7, and H10N8 Subtype Avian Influenza Viruses Circulating in Ducks

Miaomiao Zhang; Xingxing Zhang; Kaidi Xu; Qiaoyang Teng; Qinfang Liu; Xuesong Li; Jianmei Yang; Jianqing Xu; Hongjun Chen; Xiaoyan Zhang; Zejun Li

doi:10.1038/srep34489

Characterization of the Pathogenesis of H10N3, H10N7, and H10N8 Subtype Avian Influenza Viruses Circulating in Ducks

Sci Rep. 2016 Sep 28:6:34489. doi: 10.1038/srep34489.

Authors

Miaomiao Zhang^{1

2}, Xingxing Zhang², Kaidi Xu², Qiaoyang Teng^{2

3}, Qinfang Liu^{2

3}, Xuesong Li^{2

3}, Jianmei Yang^{2

3}, Jianqing Xu¹, Hongjun Chen^{2

3}, Xiaoyan Zhang¹, Zejun Li^{2

3}

Affiliations

¹ Shanghai Public Health Clinical Center, Fudan University Shanghai 201508 P. R. China.
² Shanghai Veterinary Research Institute, Chinese Academic of Agricultural Sciences, Shanghai 200241 P. R. China.
³ Animal Influenza Virus Evolution and Pathogenesis Innovation Team of The Agricultural Science and Technology Innovation Team, Shanghai 200241 P. R. China.

Abstract

Three H10 subtype avian influenza viruses were isolated from domestic ducks in China, designated as SH602/H10N8, FJ1761/H10N3 and SX3180/H10N7, with an intravenous pathogenicity index (IVPI) of 0.39, 1.60, and 1.27, respectively. These H10 viruses showed a complex pathology pattern in different species, although full genome characterizations of the viruses could not identify any molecular determinant underlying the observed phenotypes. Our findings describe the pathobiology of the three H10 subtype AIVs in chickens, ducks, and mice. FJ1761/H10N3 evolved E627K and Q591K substitutions in the gene encoding the PB2 protein in infected mice with severe lung damage, suggesting that H10 subtype avian influenza viruses are a potential threat to mammals.