Abstract
In recent years, rapid discoveries have been made relating to Ca2+ handling at specific organelles that have important implications for whole-cell Ca2+ homeostasis. In particular, the structures of the endoplasmic reticulum (ER) Ca2+ channels revealed by electron cryomicroscopy (cryo-EM), continuous updates on the structure, regulation, and role of the mitochondrial calcium uniporter (MCU) complex, and the analysis of lysosomal Ca2+ signaling are milestones on the route towards a deeper comprehension of the complexity of global Ca2+ signaling. In this review we summarize recent discoveries on the regulation of interorganellar Ca2+ homeostasis and its role in pathophysiology.
Copyright © 2016 Elsevier Ltd. All rights reserved.
Publication types
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Review
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Calcium / metabolism*
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Calcium Channels / genetics
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Calcium Channels / metabolism
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Calcium Signaling / physiology*
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Endoplasmic Reticulum / metabolism*
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Gene Expression Regulation / physiology*
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Homeostasis
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Humans
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Lysosomes / metabolism*
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Mitochondria / metabolism*
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Muscle, Skeletal / metabolism
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Muscle, Skeletal / ultrastructure
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Muscle, Striated / metabolism
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Muscle, Striated / ultrastructure
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ORAI1 Protein / genetics
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ORAI1 Protein / metabolism
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Ryanodine Receptor Calcium Release Channel / genetics
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Ryanodine Receptor Calcium Release Channel / metabolism
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Sarcoplasmic Reticulum Calcium-Transporting ATPases / genetics
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Sarcoplasmic Reticulum Calcium-Transporting ATPases / metabolism
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Stromal Interaction Molecule 1 / genetics
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Stromal Interaction Molecule 1 / metabolism
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Type C Phospholipases / genetics
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Type C Phospholipases / metabolism
Substances
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Calcium Channels
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ORAI1 Protein
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Ryanodine Receptor Calcium Release Channel
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Stromal Interaction Molecule 1
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mitochondrial calcium uniporter
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Type C Phospholipases
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Sarcoplasmic Reticulum Calcium-Transporting ATPases
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Calcium