A potent, tissue-selective, synthetic inhibitor of HMG-CoA reductase

J Med Chem. 1989 Sep;32(9):2038-41. doi: 10.1021/jm00129a004.

Authors

N Balasubramanian¹, P J Brown, J D Catt, W T Han, R A Parker, S Y Sit, J J Wright

Affiliation

¹ Cardiovascular Division, Bristol Myers Co., Wallingford, Connecticut 06492.

PMID: 2769677
DOI: 10.1021/jm00129a004

No abstract available

MeSH terms

Animals
Anticholesteremic Agents / chemical synthesis
Anticholesteremic Agents / pharmacology
Butadienes / chemical synthesis*
Butadienes / pharmacology
Hydroxymethylglutaryl-CoA Reductase Inhibitors*
Microsomes, Liver / drug effects
Microsomes, Liver / enzymology*
Pyrans / chemical synthesis*
Pyrones / chemical synthesis*
Pyrones / pharmacology
Rats
Structure-Activity Relationship

Substances

Anticholesteremic Agents
Butadienes
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Pyrans
Pyrones
BMY 22089