Cutaneous and Visceral Chronic Granulomatous Disease Triggered by a Rubella Virus Vaccine Strain in Children With Primary Immunodeficiencies

Bénédicte Neven; Philippe Pérot; Julie Bruneau; Marlene Pasquet; Marie Ramirez; Jean-Sébastien Diana; Stéphanie Luzi; Nicole Corre-Catelin; Christophe Chardot; Despina Moshous; Stéphanie Leclerc Mercier; Nizar Mahlaoui; Nathalie Aladjidi; Brigitte Le Bail; Marc Lecuit; Christine Bodemer; Thierry Jo Molina; Stéphane Blanche; Marc Eloit

doi:10.1093/cid/ciw675

Cutaneous and Visceral Chronic Granulomatous Disease Triggered by a Rubella Virus Vaccine Strain in Children With Primary Immunodeficiencies

Clin Infect Dis. 2017 Jan 1;64(1):83-86. doi: 10.1093/cid/ciw675. Epub 2016 Oct 6.

Authors

Bénédicte Neven^{1

2

3}, Philippe Pérot^{4

5}, Julie Bruneau⁶, Marlene Pasquet⁷, Marie Ramirez⁴, Jean-Sébastien Diana^{1

2}, Stéphanie Luzi⁸, Nicole Corre-Catelin⁹, Christophe Chardot¹⁰, Despina Moshous^{1

2

3}, Stéphanie Leclerc Mercier^{6

11}, Nizar Mahlaoui^{2

3}, Nathalie Aladjidi¹², Brigitte Le Bail¹³, Marc Lecuit^{1

14

3

4}, Christine Bodemer¹¹, Thierry Jo Molina^{1

6}, Stéphane Blanche^{1

2

3}, Marc Eloit⁴

Affiliations

¹ Sorbonne Paris Cité, Paris Descartes University, Institut Imagine.
² Paediatric Haemato-Immunology Unit.
³ National Reference Centre for Primary Immune Deficiencies.
⁴ Biology of Infection Unit, Laboratory of Pathogen Discovery, Inserm U1117.
⁵ Biomics, Centre d'Innovation et de Recherche Technologique.
⁶ Department of Pathology.
⁷ Hematology and Immunology Pediatric Department, CHU Toulouse, Center of Research in Cancerology of Toulouse, Team 16, Institut Universitaire du Cancer de Toulouse-Oncopole.
⁸ Department of Radiology.
⁹ Investigation Clinique et Accès aux Ressources Biologiques, Institut Pasteur, Paris.
¹⁰ Department of Pediatric Surgery.
¹¹ Department of Dermatology.
¹² Pediatric Oncology Hematology Unit/CEREVANCE/CIC 1401, Inserm Centre d'Investigation Clinique Plurithématique, University Hospital of Bordeaux, Pediatric Hospital.
¹³ Department of Pathology, Hôpital des Enfants-Hôpital Pellegrin, Bordeaux, France.
¹⁴ Department of Infectious Diseases, Hôpital Necker-Enfants Malades, Assistance Publique Hôpitaux de Paris.

PMID: 27810866
DOI: 10.1093/cid/ciw675

Abstract

Persistence of rubella live vaccine has been associated with chronic skin granuloma in 3 children with primary immunodeficiency. We describe 6 additional children with these findings, including 1 with visceral extension to the spleen.

Keywords: granuloma; rubella; skin; spleen; vaccine.

Publication types

Case Reports

MeSH terms

Biopsy
Capsid Proteins / genetics
Child
Female
Granulomatous Disease, Chronic / diagnosis*
Granulomatous Disease, Chronic / etiology*
Homeodomain Proteins / genetics
Humans
Immunohistochemistry
Immunologic Deficiency Syndromes / complications*
Immunologic Deficiency Syndromes / diagnosis
Immunologic Deficiency Syndromes / genetics
Male
Mutation
Reverse Transcriptase Polymerase Chain Reaction
Rubella Vaccine / adverse effects*
Rubella Vaccine / genetics
Skin / pathology
Skin / virology
Spleen / pathology
Spleen / virology

Substances

Capsid Proteins
Homeodomain Proteins
Rubella Vaccine
RAG-1 protein