Systematic analysis of telomere length and somatic alterations in 31 cancer types

Nat Genet. 2017 Mar;49(3):349-357. doi: 10.1038/ng.3781. Epub 2017 Jan 30.

Abstract

Cancer cells survive cellular crisis through telomere maintenance mechanisms. We report telomere lengths in 18,430 samples, including tumors and non-neoplastic samples, across 31 cancer types. Telomeres were shorter in tumors than in normal tissues and longer in sarcomas and gliomas than in other cancers. Among 6,835 cancers, 73% expressed telomerase reverse transcriptase (TERT), which was associated with TERT point mutations, rearrangements, DNA amplifications and transcript fusions and predictive of telomerase activity. TERT promoter methylation provided an additional deregulatory TERT expression mechanism. Five percent of cases, characterized by undetectable TERT expression and alterations in ATRX or DAXX, demonstrated elongated telomeres and increased telomeric repeat-containing RNA (TERRA). The remaining 22% of tumors neither expressed TERT nor harbored alterations in ATRX or DAXX. In this group, telomere length positively correlated with TP53 and RB1 mutations. Our analysis integrates TERT abnormalities, telomerase activity and genomic alterations with telomere length in cancer.

MeSH terms

  • DNA Methylation / genetics
  • Glioma / genetics
  • Humans
  • Neoplasms / genetics*
  • Point Mutation / genetics*
  • Promoter Regions, Genetic / genetics
  • Retinoblastoma Binding Proteins / genetics
  • Sarcoma / genetics
  • Telomerase / genetics
  • Telomere / genetics*
  • Tumor Suppressor Protein p53 / genetics
  • Ubiquitin-Protein Ligases / genetics

Substances

  • RB1 protein, human
  • Retinoblastoma Binding Proteins
  • Tumor Suppressor Protein p53
  • Ubiquitin-Protein Ligases
  • Telomerase