Fecal Microbiota Transplantation

Stephen M Vindigni; Christina M Surawicz

doi:10.1016/j.gtc.2016.09.012

Fecal Microbiota Transplantation

Gastroenterol Clin North Am. 2017 Mar;46(1):171-185. doi: 10.1016/j.gtc.2016.09.012.

Authors

Stephen M Vindigni¹, Christina M Surawicz²

Affiliations

¹ Division of Gastroenterology, Department of Medicine, School of Medicine, University of Washington, 1959 Northeast Pacific Street, Box 356424, Seattle, WA 98195-6424, USA. Electronic address: vindigni@uw.edu.
² Division of Gastroenterology, Department of Medicine, University of Washington, 325 9th Avenue, Box 359773, Seattle, WA 98104, USA.

PMID: 28164849
DOI: 10.1016/j.gtc.2016.09.012

Abstract

Fecal microbiota transplantation (FMT) is the transfer of stool from a healthy donor into the colon of a patient whose disease is a result of an altered microbiome, with the goal of restoring the normal microbiota and thus curing the disease. The most effective and well-studied indication for FMT is recurrent Clostridium difficile infection. At this time, there is insufficient evidence to recommend FMT for other gastrointestinal diseases, but studies are under way. There is also insufficient evidence to recommend FMT for nongastrointestinal diseases at this time. The field is rapidly emerging.

Keywords: Clostridium difficile; FMT; Fecal microbiota transplant; Microbiome; Stool transplant.

Publication types

Review

MeSH terms

Clostridioides difficile*
Clostridium Infections / therapy*
Donor Selection
Dysbiosis / therapy*
Fecal Microbiota Transplantation* / adverse effects
Fecal Microbiota Transplantation* / methods
Humans
Inflammatory Bowel Diseases / therapy
Informed Consent
Patient Selection*