Mechanisms of Cell Polarity-Controlled Epithelial Homeostasis and Immunity in the Intestine

Leon J Klunder; Klaas Nico Faber; Gerard Dijkstra; Sven C D van IJzendoorn

doi:10.1101/cshperspect.a027888

Mechanisms of Cell Polarity-Controlled Epithelial Homeostasis and Immunity in the Intestine

Cold Spring Harb Perspect Biol. 2017 Jul 5;9(7):a027888. doi: 10.1101/cshperspect.a027888.

Authors

Leon J Klunder¹, Klaas Nico Faber², Gerard Dijkstra², Sven C D van IJzendoorn¹

Affiliations

¹ Department of Cell Biology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, the Netherlands.
² Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, the Netherlands.

Abstract

Intestinal epithelial cell polarity is instrumental to maintain epithelial homeostasis and balance communications between the gut lumen and bodily tissue, thereby controlling the defense against gastrointestinal pathogens and maintenance of immune tolerance to commensal bacteria. In this review, we highlight recent advances with regard to the molecular mechanisms of cell polarity-controlled epithelial homeostasis and immunity in the human intestine.

Publication types

Review

MeSH terms

Cell Polarity*
Epithelial Cells
Homeostasis
Immunity, Innate
Intestines / cytology*
Intestines / immunology
Microvilli / immunology
Models, Theoretical