Intensive care medicine research agenda on cardiac arrest

Jerry P Nolan; Robert A Berg; Stephen Bernard; Bentley J Bobrow; Clifton W Callaway; Tobias Cronberg; Rudolph W Koster; Peter J Kudenchuk; Graham Nichol; Gavin D Perkins; Tom D Rea; Claudio Sandroni; Jasmeet Soar; Kjetil Sunde; Alain Cariou

doi:10.1007/s00134-017-4739-7

Intensive care medicine research agenda on cardiac arrest

Intensive Care Med. 2017 Sep;43(9):1282-1293. doi: 10.1007/s00134-017-4739-7. Epub 2017 Mar 11.

Authors

Jerry P Nolan^{1

2}, Robert A Berg^{3

4}, Stephen Bernard⁵, Bentley J Bobrow⁶, Clifton W Callaway⁷, Tobias Cronberg⁸, Rudolph W Koster⁹, Peter J Kudenchuk¹⁰, Graham Nichol¹¹, Gavin D Perkins¹², Tom D Rea¹³, Claudio Sandroni¹⁴, Jasmeet Soar¹⁵, Kjetil Sunde^{16

17}, Alain Cariou¹⁸

Affiliations

¹ School of Clinical Sciences, University of Bristol, Bristol, UK. jerry.nolan@nhs.net.
² Anaesthesia and Intensive Care Medicine, Royal United Hospital, Bath, UK. jerry.nolan@nhs.net.
³ Pediatric Critical Care Medicine, Russell Raphaely Endowed Chair of Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, USA.
⁴ Anesthesiology and Critical Care Medicine, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, USA.
⁵ Ambulance Victoria, Victoria, Australia.
⁶ Department of Emergency Medicine, University of Arizona College of Medicine, Tucson, AZ, USA.
⁷ Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
⁸ Department of Clinical Sciences Lund, Neurology, Skane University Hospital, Lund University, Lund, Sweden.
⁹ Department of Cardiology, Academic Medical Center, Meibergdreef, Amsterdam, The Netherlands.
¹⁰ Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA, USA.
¹¹ University of Washington-Harborview Center for Prehospital Emergency Care, University of Washington, Seattle, WA, USA.
¹² Critical Care Medicine, Warwick Medical School and Heart of England NHS Foundation Trust, University of Warwick, Coventry, CV4 7AL, UK.
¹³ University of Washington, Seattle, WA, USA.
¹⁴ Department of Anaesthesiology and Intensive Care, Catholic University School of Medicine, Largo Gemelli, 8, 00168, Rome, Italy.
¹⁵ Anaesthesia and Intensive Care Medicine, North Bristol NHS Trust, Southmead Hospital, Bristol, BS10 5NB, UK.
¹⁶ Department of Anaesthesiology, Division of Emergencies and Critical Care, Oslo University Hospital, Oslo, Norway.
¹⁷ Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
¹⁸ Medical ICU, Cochin Hospital (AP-HP), Paris-Cardiovascular-Research-Centre, INSERM U970 (Sudden Death Expertize Centre), Université Paris-Descartes-Sorbonne-Paris-Cité, Paris, France.

PMID: 28285322
DOI: 10.1007/s00134-017-4739-7

Abstract

Over the last 15 years, treatment of comatose post-cardiac arrest patients has evolved to include therapeutic strategies such as urgent coronary angiography with percutaneous coronary intervention (PCI), targeted temperature management (TTM)-requiring mechanical ventilation and sedation-and more sophisticated and cautious prognostication. In 2015, collaboration between the European Resuscitation Council (ERC) and the European Society for Intensive Care Medicine (ESICM) resulted in the first European guidelines on post-resuscitation care. This review addresses the major recent advances in the treatment of cardiac arrest, recent trials that have challenged current practice and the remaining areas of uncertainty.

Keywords: Advanced life support; Basic life support; Cardiac arrest; Cardiopulmonary resuscitation; Post-resuscitation care; Prognostication.

Publication types

Review

MeSH terms

Biomedical Research
Cardiopulmonary Resuscitation / education
Cardiopulmonary Resuscitation / methods*
Coma / therapy
Coronary Angiography / methods*
Critical Care
Humans
Hypothermia, Induced / methods*
Neuroprotective Agents / therapeutic use
Out-of-Hospital Cardiac Arrest / diagnosis
Out-of-Hospital Cardiac Arrest / mortality
Out-of-Hospital Cardiac Arrest / therapy*
Outcome Assessment, Health Care
Percutaneous Coronary Intervention / methods
Randomized Controlled Trials as Topic
Respiration, Artificial / methods
Time-to-Treatment

Substances

Neuroprotective Agents