Abstract
The formation of C-C bonds in an enantioselective fashion to create complex polycyclic scaffolds in the hapalindole- and fischerindole- type alkaloids from Stigonematales cyanobacteria represents a compelling and urgent challenge in adapting microbial biosynthesis as a catalytic platform in drug development. Here we determine the biochemical basis for tri- and tetracyclic core formation in these secondary metabolites, involving a new class of cyclases that catalyze a complex cyclization cascade.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Biocatalysis*
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Carbon-Carbon Lyases / metabolism*
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Cyanobacteria / metabolism
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Cyclization
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Indole Alkaloids / chemistry
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Indole Alkaloids / metabolism*
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Indoles / chemistry
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Indoles / metabolism*
Substances
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Indole Alkaloids
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Indoles
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fischerindole
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Carbon-Carbon Lyases
Associated data
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PubChem-Substance/329588501
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PubChem-Substance/329588503
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PubChem-Substance/329588504
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PubChem-Substance/329588505
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PubChem-Substance/329588506
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PubChem-Substance/329588507
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PubChem-Substance/329588508
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PubChem-Substance/329588509
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PubChem-Substance/329588510
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PubChem-Substance/329588502