Zika Virus

Ryan F Relich; Michael Loeffelholz

doi:10.1016/j.cll.2017.01.002

Zika Virus

Clin Lab Med. 2017 Jun;37(2):253-267. doi: 10.1016/j.cll.2017.01.002. Epub 2017 Mar 30.

Authors

Ryan F Relich¹, Michael Loeffelholz²

Affiliations

¹ Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 350 West 11th Street, Suite 6027, Indianapolis, IN 46202, USA. Electronic address: rrelich@iupui.edu.
² Clinical Microbiology Laboratory, Department of Pathology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0740, USA.

PMID: 28457349
DOI: 10.1016/j.cll.2017.01.002

Abstract

The ongoing epidemic of Zika fever in the Western Hemisphere has drawn considerable attention from the medical and scientific communities as well as the general public, largely because of its association with birth defects and postinfectious sequelae. Since its appearance in Brazil in 2015, Zika virus has spread to more than 45 countries in the Western Hemisphere and has caused countless infections. To date, no treatment or vaccine exists, but a considerable multinational effort to halt Zika virus transmission is underway. This article reviews the basic biology, epidemiology, pathophysiology, diagnosis, and treatment of Zika virus and Zika fever.

Keywords: Arbovirus; Autochthonous; Birth defects; Flaviviridae; Flavivirus; Guillain-Barré syndrome; Microcephaply.

Publication types

Review

MeSH terms

Congenital Abnormalities / virology
Disease Outbreaks
Epidemics
Humans
Zika Virus Infection* / diagnosis
Zika Virus Infection* / epidemiology
Zika Virus Infection* / physiopathology
Zika Virus Infection* / therapy
Zika Virus*