Long spinal cord lesions in a patient with pathologically proven multiple sclerosis

Junji Komatsu; Kenji Sakai; Mitsutoshi Nakada; Kazuo Iwasa; Masahito Yamada

doi:10.1016/j.jocn.2017.03.022

Long spinal cord lesions in a patient with pathologically proven multiple sclerosis

J Clin Neurosci. 2017 Aug:42:106-108. doi: 10.1016/j.jocn.2017.03.022. Epub 2017 Apr 29.

Authors

Junji Komatsu¹, Kenji Sakai², Mitsutoshi Nakada³, Kazuo Iwasa⁴, Masahito Yamada⁵

Affiliations

¹ Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, Kanazawa 920-8640, Japan. Electronic address: kjunji@med.kanazawa-u.ac.jp.
² Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, Kanazawa 920-8640, Japan. Electronic address: ksakai@med.kanazawa-u.ac.jp.
³ Department of Neurosurgery, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa 920-8640, Japan. Electronic address: mnakada@med.kanazawa-u.ac.jp.
⁴ Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, Kanazawa 920-8640, Japan. Electronic address: neuiwasa@med.kanazawa-u.ac.jp.
⁵ Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, Kanazawa 920-8640, Japan. Electronic address: m-yamada@med.kanazawa-u.ac.jp.

PMID: 28465080
DOI: 10.1016/j.jocn.2017.03.022

Abstract

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. We report the case of a 50-year-old man who presented with progressive gait ataxia. Brain magnetic resonance imaging (MRI) on fluid-attenuated inversion recovery revealed a hyperintense lesion in the right temporal white matter. The spinal cord showed a long hyperintense lesion between the vertebral levels C6 and L1 on T2-weighted MRI. Biopsied tissues from the brain lesion demonstrated features of inflammatory demyelination with preservation of astrocytes, consistent with typical MS. This is the first reported case of pathologically proven MS with longitudinally extensive spinal cord lesions.

Keywords: Longitudinally extensive spinal cord lesion; Magnetic resonance imaging; Multiple sclerosis; Pathology.

Publication types

Case Reports

MeSH terms

Cervical Vertebrae / pathology
Humans
Lumbar Vertebrae / pathology
Magnetic Resonance Imaging
Male
Middle Aged
Multiple Sclerosis / pathology*
Spinal Cord / pathology*
Temporal Lobe / pathology
White Matter / pathology