Type 2 diabetes is an independent risk factor for dementia conversion in patients with mild cognitive impairment

J Diabetes Complications. 2017 Aug;31(8):1272-1274. doi: 10.1016/j.jdiacomp.2017.04.018. Epub 2017 Apr 19.

Abstract

Aims: To explore whether type 2 diabetes (T2D) is a risk factor for dementia conversion in patients with mild cognitive impairment (MCI).

Methods: A longitudinal nested case-control study in which 101 T2D patients and 101 non-diabetic patients with MCI matched by age and gender were included.

Results: The dementia conversion rate was 57.4% in T2D patients vs. 42.6% in non-diabetic subjects (p=0.02). T2D and APOE ε4 allele were independent risk factors for developing dementia.

Conclusion: T2D is an independent risk factor for dementia conversion in MCI patients. This finding has significant clinical implications.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alleles
  • Apolipoprotein E4 / genetics
  • Case-Control Studies
  • Cognitive Dysfunction / complications*
  • Cognitive Dysfunction / genetics
  • Cognitive Dysfunction / physiopathology
  • Dementia / complications*
  • Dementia / epidemiology
  • Dementia / etiology
  • Dementia / genetics
  • Diabetes Mellitus, Type 2 / complications*
  • Diabetes Mellitus, Type 2 / psychology
  • Diabetic Retinopathy / complications
  • Diabetic Retinopathy / epidemiology
  • Disease Progression
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Humans
  • Incidence
  • Longitudinal Studies
  • Male
  • Polymorphism, Genetic
  • Prevalence
  • Retrospective Studies
  • Risk Factors
  • Spain / epidemiology

Substances

  • Apolipoprotein E4